Fluorescent study of the keto-enol equilibrium of 5-fluorouracil tautomers in aqueous solutions

被引：0

作者：

M. V. Sultanbaev

S. S. Ostakhov

Sh. Kh. Gantsev

F. A. Khalilullin

V. P. Kazakov

机构：

[1] Russian Academy of Sciences,Institute of Organic Chemistry, Ufa Research Center

[2] Bashkir State Medical University,undefined

来源：

High Energy Chemistry | 2010年 / 44卷

关键词：

Excitation Spectrum; Enol; High Energy Chemistry; Tryptophan Fluorescence; Fluorescence Excitation Spectrum;

D O I：

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学科分类号：

摘要：

A spectral-luminescent study of the keto-enol tautomerism of 5-fluorouracil (FU) has been performed. A discrepancy between the absorption and fluorescence (FL) excitation spectra of aqueous FU solutions (pH 7) has been established. Photoexcitation at the long-wavelength band (340 nm) of the FU excitation spectrum made it possible to detect the fluorescence of its dienol tautomer (λmax = 440 nm). The quenching of tryptophan fluorescence (K = 15 × 103 l/mol) and blood fluorescence by 5-fluorouracil has been investigated.

引用

页码：383 / 386

页数：3