Fluorescent study of the keto-enol equilibrium of 5-fluorouracil tautomers in aqueous solutions

被引：0
作者：
M. V. Sultanbaev
S. S. Ostakhov
Sh. Kh. Gantsev
F. A. Khalilullin
V. P. Kazakov
机构：
[1] Russian Academy of Sciences,Institute of Organic Chemistry, Ufa Research Center
[2] Bashkir State Medical University,undefined
来源：
High Energy Chemistry | 2010年 / 44卷
关键词：
Excitation Spectrum; Enol; High Energy Chemistry; Tryptophan Fluorescence; Fluorescence Excitation Spectrum;
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摘要：
A spectral-luminescent study of the keto-enol tautomerism of 5-fluorouracil (FU) has been performed. A discrepancy between the absorption and fluorescence (FL) excitation spectra of aqueous FU solutions (pH 7) has been established. Photoexcitation at the long-wavelength band (340 nm) of the FU excitation spectrum made it possible to detect the fluorescence of its dienol tautomer (λmax = 440 nm). The quenching of tryptophan fluorescence (K = 15 × 103 l/mol) and blood fluorescence by 5-fluorouracil has been investigated.
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页码：383 / 386
页数：3
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