Synthesis and analgesic activity of alkyl-substituted octahydro-2H-chromenols

被引：0
作者：
I. V. Il’ina
D. V. Korchagina
E. A. Morozova
T. G. Tolstikova
K. P. Volcho
N. F. Salakhutdinov
机构：
[1] Siberian Branch of the Russian Academy of Sciences,N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry
来源：
Russian Chemical Bulletin | 2022年 / 71卷
关键词：
monoterpenes; montmorillonite K10; heterocyclic compounds; analgesic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of new compounds with hydrogenated 2H-chromene framework was synthesized starting from aliphatic aldehydes and available p-menthane monoterpenoid (−)-isopulegol in the presence of montmorillonite K10. These compounds were formed as a pair of diastereoisomers, which were isolated individually using column chromatography. Some of the compounds obtained were found to exhibit high analgesic activity in in vivo tests.
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页码：2482 / 2488
页数：6
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