Combined Multichannel Intraluminal Impedance-pH (MII-pH): Multicenter Report of Normal Values from 117 Children

被引：39

作者：

Mousa H. ^{[1
,2
]}

Machado R. ^{[1
]}

Orsi M. ^{[4
]}

Chao C.S. ^{[3
]}

Alhajj T. ^{[1
]}

Alhajj M. ^{[1
]}

Port C. ^{[3
]}

Skaggs B. ^{[1
]}

Woodley F.W. ^{[1
,2
]}

机构：

[1] Division of Pediatric Gastroenterology, Nationwide Children’s Hospital, 700 Children’s Drive, JW 1985, Columbus, OH

[2] The Department of Pediatrics, The Ohio State University, Nationwide Children Hospital, Columbus, OH

[3] Inova Children’s Hospital, Falls Church, VA

[4] The Pediatric Gastroenterology, Hepatology and Transplant Unit, Hospital Italiano, Buenos Aires

来源：

Current Gastroenterology Reports | 2014年 / 16卷 / 8期

关键词：

AGER; Gastroesophageal reflux; GER; Impedance; NAGER; Non-acid GER; Normal values; Reference values; Symptom association probability;

D O I：

10.1007/s11894-014-0400-6

中图分类号：

学科分类号：

摘要：

Although combined multichannel intraluminal impedance/esophageal pH monitoring (MII-pH) has replaced prolonged pH monitoring alone for assessing gastroesophageal reflux (GER) in the pediatric population, it does so in the absence of reference values for non-acid GER (NAGER). The purpose of this study was to identify a normal range of NAGER impedance values for infants and children. We evaluated EPM/MII tracings for patients referred for GER assessment to Nationwide Children’s Hospital (Columbus, OH), Inova Children’s Hospital, and Hospital Italiano (Buenos Aires, Argentina). We excluded tracings from patients who had AGER indices greater than 50 % of the upper end of normal (i.e., >3 % for children >12 months and >6 % for infants ≤12 months), had a positive temporal association of GER with symptoms, were on anti-reflux medications at the time of the study, and/or had a fundoplication prior to the study. We also excluded studies with durations shorter than 20 h. Values for NAGER percent time, NAGER episode frequency, frequency of proximal NAGER, and mean NAGER duration were calculated for upright position, recumbent, and total. Study population consisted of 46 infants (20 female [F]/26 male [M], median age 4.8 months [range 3 weeks–11.9 months]) with a median AGER index of 2.2 % (range 0.0–5.9 %) and 71 children (22 F/49 M, median age 7.2 years [range 1.3–17 years]) with a median AGER index of 1.1 % (range 0–3.0 %). Data are presented in tables in the text. The results of this study provide a range of values characteristic of infants and children with normal AGER indices and no positive temporal associations of GER with symptoms. These values may be used as references for comparison to identify infants and/or children who may be at risk of developing serious clinical manifestations due to abnormal patterns of GER. © 2014, Springer Science+Business Media New York.

引用

页码：1 / 8

页数：7

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