Insights into the Perspective Correlation Between Vitamin D and Regulation of Hormones: Thyroid and Parathyroid Hormones

Vitamin D is a vital contributor to the regulation of calcium and phosphorus homeostasis to preserve healthy bones and teeth. This was previously assumed as the only role of vitamin D, but the amount of recent studies gives it popularity as panacea for cases beyond bone mineralization especially after reporting vitamin D receptors in many human cells. This led to a growing evidence that vitamin D could have a greater effect on human health. Accordingly, several functions of vitamin D have been agreed, and in several disorders, its deficiency is crucially suggested. Current reports have also demonstrated a striking link between vitamin D and the regulation of hormones with illustrated role for vitamin D in stimulation or inhibition of the synthesis and release of different hormones, as well as the feedback of some hormones on the in vivo production of vitamin D. A variety of conditions may arise as a consequence of increased or even decreased secretion of hormones have been linked to low level of serum vitamin D, providing a significance for reviewing of this regulation biologically and physiologically. This review is the first part of series to highlight the correlation between vitamin D and regulation of hormones in addition to reporting the link between deficiency of vitamin D and the hormone-associated medical disorders. Vitamin D’s role in regulation of hormone secretion and its associations with thyroid and parathyroid hormones will be considered in the current review.