Hematopoietic Stem Cell Transplantation for Fanconi Anemia: A Single Center Experience from India

被引:0
作者
Divya Doval
Dharma Choudhary
Sanjeev Kumar Sharma
Vipin Khandelwal
Meet Kumar
Anil Handoo
Rasika Setia
机构
[1] BLK Superspeciality Hospital,Department of Hemato
[2] BLK Superspeciality Hospital,Oncology and Bone Marrow Transplantation
[3] BLK Superspeciality Hospital,Laboratory Services, Department of Haematology
来源
Indian Journal of Hematology and Blood Transfusion | 2020年 / 36卷
关键词
Fanconi anemia; HSCT; Matched sibling donor;
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学科分类号
摘要
Hematopoietic stem cell transplantation (HSCT) is the only treatment option for the hematological manifestations of Fanconi anemia (FA). Fludarabine based reduced intensity conditioning regimens have helped in improving outcomes significantly in FA patients. We retrospectively analyzed the outcomes of FA patients who underwent allogeneic HSCT at BLK Superspeciality Hospital, New Delhi from June 2011 to September 2019. Twenty FA patients underwent 23 transplants at our center. Overall survival and disease free survival were 65% and 50%, respectively at a median of 23 months. Overall mortality was 30%. HSCT for FA is a feasible option even in developing countries although children present late to transplant centers after multiple transfusions and infections.
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页码:565 / 568
页数:3
相关论文
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