NF-kappaB and Apoptosis in Mammary Epithelial Cells

被引：0
作者：
Richard W. E. Clarkson
Christine J. Watson
机构：
来源：
Journal of Mammary Gland Biology and Neoplasia | 1999年 / 4卷
关键词：
NF-KAPPAB; APOPTOSIS; MAMMARY GLAND; EPITHELIA;
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摘要：
A number of transcription factors have beenidentified as regulators of mammary development,including Stat5 and C/EBPβ (1-3). In this review wesummarize evidence which suggests that the NF-κBfamily of transcription factors also has a role inmammary gland development. NF-κB was originallydescribed as a mediator of inflammatory reactions andcellular responses to viral pathogens. More recently it has been shown to possess an anti-apoptoticeffect in a variety of cell types by regulatingapoptosis-related genes. In the light of this functionin other tissues, and the observation that aberrant activation of NF-κB can be associatedwith mammary tumors, we discuss the potential role ofthis transcription factor in modulating mammaryepithelial apoptosis and involution of the mammarygland.
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页码：165 / 175
页数：10
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