NF-kappaB and Apoptosis in Mammary Epithelial Cells

被引：0
作者：
Richard W. E. Clarkson
Christine J. Watson
机构：
来源：
Journal of Mammary Gland Biology and Neoplasia | 1999年 / 4卷
关键词：
NF-KAPPAB; APOPTOSIS; MAMMARY GLAND; EPITHELIA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A number of transcription factors have beenidentified as regulators of mammary development,including Stat5 and C/EBPβ (1-3). In this review wesummarize evidence which suggests that the NF-κBfamily of transcription factors also has a role inmammary gland development. NF-κB was originallydescribed as a mediator of inflammatory reactions andcellular responses to viral pathogens. More recently it has been shown to possess an anti-apoptoticeffect in a variety of cell types by regulatingapoptosis-related genes. In the light of this functionin other tissues, and the observation that aberrant activation of NF-κB can be associatedwith mammary tumors, we discuss the potential role ofthis transcription factor in modulating mammaryepithelial apoptosis and involution of the mammarygland.
引用
收藏
页码：165 / 175
页数：10
相关论文
共 353 条
  • [21] Bakiri L.(1995)Characterization of mechanisms involved in transrepression of NF-kappa-B by activated glucocorticoid receptors Nature 376 167-330
  • [22] Yaniv M.(1995)Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa-B Cell 80 321-340
  • [23] Steller H.(1995)Targeted disruption of the p50 subunit of NF-kappa-B leads to multifocal defects in immune-response s Cell 80 331-912
  • [24] Miller L. J.(1993)Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa-B/Rel family Cell 75 899-20
  • [25] Marx J.(1996)High-levels of c-Rel expression are associated with programmed cell-death in the developing avian embryo and in bone-marrow cells Cell 87 13-111
  • [26] Sen R.(1998)NF-kappa B: Ten years after Trends Cell Biol. 8 107-23
  • [27] Baltimore D.(1996)Inhibition of TNF-induced apoptosis by NF-kappa B J. Cell Biol. 134 13-789
  • [28] Collins T.(1996)Bcl-2 down-regulates the activity of transcription factor NF-kappa B induced upon apoptosis Science 274 787-787
  • [29] Ghosh S.(1996)Suppression of TNF-alpha-induced apoptosis by NF-kappa B Science 274 784-1488
  • [30] May M. J.(1995)TNF-and career therapy-induced apoptosis: Potentiation by inhibition of NF-kappa-B Science 267 1485-784
12345678910