Enantioselectivity of 6-O-alkyldimethylsilyl-2,3-di-O-methyl-β-cyclodextrins as chiral stationary phases in capillary GC

被引：0
作者：
B. E. Kim
K. -P. Lee
K. -S. Park
S. H. Lee
J. H. Park
机构：
[1] Research Institute of Industrial Science and Technology,Department of Chemistry
[2] Kyungpook National University,Department of Chemistry
[3] Yeungnam University,undefined
来源：
Chromatographia | 1997年 / 46卷
关键词：
Gas chromatography; Capillary columns; Enantiomer resolution; Chiral stationary phase; Derivatized cyclodextrins;
D O I：
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中图分类号：
学科分类号：
摘要：
Three new 2,3-di-O-methyl-β-cyclodextrins having different 6-O-alkyldimethylsilyl groups, 6-O-isopropyldimethylsilyl-2,3-di-O-methyl-β-cyclodextrin (IPDM-β-CD), 6-O-thexyldimethylsilyl-2,3-di-O-methyl-β-cyclodextrin (TXDM-β-CD) and 6-O-cyclohexyldimethylsilyl-2,3-di-O-methyl-β-cyclodextrin (CHDM-β-CD), have been prepared and their enantioselectivities for the separation of a range of test racemic compounds in capillary gas chromatography investigated. IPDM-β-CD gave good separations of all of the test componds studied while TXDM-β-CD showed the highest enantioselectivity for the test compounds except for three nonpolar compounds. CHDM-β-CD showed very low enantioselectivity. Differences in enantioselectivities among the CD derivatives were rationalized in terms of the steric hindrance and hydrophobicity effects influencing the inclusion of the guest in the host CD derivatives.
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页码：145 / 150
页数：5
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