Design and synthesis of positional isomers of 1-alkyl-2-trifluoromethyl-5 or 6-substituted benzimidazoles and their antimicrobial activity

被引:0
|
作者
G. Sathaiah
A. Ravi Kumar
A. Chandra Shekhar
K. Raju
P. Shanthan Rao
B. Narsaiah
A. Raghuram Reddy
D. Lakshmi
B. Sridhar
机构
[1] Indian Institute of Chemical Technology,Fluoroorganic Division
[2] Indian Institute of Chemical Technology,Department of X
[3] Kakatiya University,ray Crystallography
来源
Medicinal Chemistry Research | 2013年 / 22卷
关键词
Benzimidazole; Trifluoromethyl; Antifungal; Antibacterial;
D O I
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中图分类号
学科分类号
摘要
A series of novel positional isomers of 1-alkyl-2-trifluoromethyl benzimidazole derivatives 3a–j and 4a–j have been synthesized and screened for antibacterial activity against gram positive bacteria viz, Bacillus subtilis, Staphylococcus aureus and gram negative bacteria viz., Escherichia coli, Pseudomonas aeruginosa and antifungal activity against Candida albicans, Aspergillus niger, Rhizopus oryzae and Saccharomyces cerevisiae. Results indicate that compounds 3b, 4b were having promising antibacterial and antifungal activity.
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页码:1229 / 1237
页数:8
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