Evaluation of urinary miRNA-96 as a potential biomarker for bladder cancer diagnosis

被引：0
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作者：
Sanaa Eissa
Haidy Habib
Esraa Ali
Yossif Kotb
机构：
[1] Ain Shams University,Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine
[2] Ain Shams Faculty of Medicine,Oncology Diagnostic Unit
来源：
Medical Oncology | 2015年 / 32卷
关键词：
Bilharziasis; Marker; Real time PCR; Urine cytology;
D O I：
暂无
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学科分类号：
摘要：
For bladder cancer, a new diagnostic marker is needed to avoid painful cystoscopy. The aim of this study was to explore the efficacy of urinary miRNA-96 as molecular marker in bladder cancer diagnosis and its relation to bilharziasis. Urine cytology, serologic assessment of schistosomiasis and estimation of miRNA-96 by real-time PCR were carried out for 94 bladder cancer patients, 30 benign bladder lesions and 60 healthy individuals. Expression of miRNA-96 showed a significant difference among the three tested groups and also between benign and malignant bilharzial cases. Urinary miRNA-96 is a good noninvasive diagnostic biomarker for bladder cancer.
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