Treatment of newly diagnosed multiple myeloma: advances in current therapy

被引：0
作者：
Shaji Kumar
机构：
[1] Mayo Clinic,
来源：
Medical Oncology | 2010年 / 27卷
关键词：
Multiple myeloma; Risk stratification; Survival;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The past decade has seen incredible progress in the treatment of myeloma as a result of more widespread application of autologous stem cell transplantation and introduction of several new drugs. Hence, the survival of patients with this disease has significantly improved during this period. The treatment approach for patients with myeloma has undergone a paradigm shift as a result of the different choices available for treating the patients with newly diagnosed myeloma. In addition, appreciation of the heterogeneity in the outcome of these patients and the impact of genetics on the prognosis has led to efforts at developing a risk-adapted approach to treatment. This article summarizes the recent advances in the treatment of newly diagnosed myeloma and suggests a treatment algorithm for approaching newly diagnosed myeloma.
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页码：14 / 24
页数：10
相关论文
共 195 条
[1]  
Jemal A(2009)Cancer statistics CA Cancer J Clin. 59 225-249
[2]  
Siegel R(2004)Multiple myeloma N Engl J Med 351 1860-1873
[3]  
Ward E(2008)Multiple myeloma Blood 111 2962-2972
[4]  
Kyle RA(2009)Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma Leukemia 23 3-9
[5]  
Rajkumar SV(2008)Recent major improvement in long-term survival of younger patients with multiple myeloma Blood 111 2521-2526
[6]  
Kyle RA(2008)Improved survival in multiple myeloma and the impact of novel therapies Blood 111 2516-2520
[7]  
Rajkumar SV(2008)Treatment of myeloma: cure vs. control Mayo Clinic Proc 83 1142-1145
[8]  
Kyle RA(2009)Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study Blood 113 5412-5417
[9]  
Rajkumar SV(2006)Prevalence of monoclonal gammopathy of undetermined significance N Engl J Med 354 1362-1369
[10]  
Brenner H(2005)The natural history of smoldering (asymptomatic) multiple myeloma Blood 106 949a-569
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