Sandostatin Impairs Postresection Intestinal Adaptation in a Rat Model of Short Bowel Syndrome

被引：0
作者：
Igor Sukhotnik
Kamal Khateeb
Michael M. Krausz
Edmund Sabo
Leonardo Siplovich
Arnold G. Coran
Eitan Shiloni
机构：
[1] Rappaport Faculty of Medicine,
[2] Technion,undefined
[3] Carmel Medical Center,undefined
[4] Rambam Medical Center,undefined
[5] Ha-Emek Medical Center,undefined
来源：
Digestive Diseases and Sciences | 2002年 / 47卷
关键词：
sandostatin; intestinal adaptation; short bowel syndrome;
D O I：
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中图分类号：
学科分类号：
摘要：
Because of its antisecretory properties, sandostatin has been advocated for the treatment of patients with short bowel syndrome (SBS). This study was conducted to determine the effect of sandostatin on structural intestinal adaptation, cell proliferation and apoptosis in a rat model of SBS. Sprague-Dawley rats were divided into three experimental groups: Sham rats underwent bowel transection, SBS rats underwent 75% small bowel resection, and SBS-sandostatin rats underwent bowel resection and were treated with sandostatin (SBS-SND). Parameters of intestinal adaptation, enterocyte proliferation, and enterocyte apoptosis were determined on day 14 following operation. We have demonstrated that SBS-SND animals demonstrated lower (vs SBS rats) duodenal and jejunal bowel weights, jejunal and ileal mucosal weight, jejunal and ileal mucosal DNA and protein, jejunal and ileal villus height, cell proliferation index in the ileum, and enterocyte apoptosis in jejunum and ileum. We conclude that in a rat model of SBS sandostatin decreases cell proliferation and inhibits structural intestinal adaptation.
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页码：2095 / 2102
页数：7
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