Microwave-assisted synthesis of benzenesulfonohydrazide and benzenesulfonamide cyclic imide hybrid molecules and their evaluation for anticancer activity

被引：0
作者：
Anuj Kumar
Nikhil Kumar
Partha Roy
S. M. Sondhi
Anuj Sharma
机构：
[1] Indian Institute of Technology-Roorkee,Department of Chemistry
[2] Indian Institute of Technology-Roorkee,Department of Biotechnology
来源：
Medicinal Chemistry Research | 2015年 / 24卷
关键词：
Microwave; Benzenesulfonohydrazide; Benzenesulfonamide; Anticancer activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
4-Methyl benzenesulfonohydrazide (1a) and 4-methoxy benzenesulfonohydrazide (1b) on condensation with furan-2,5-dione, hexahydroisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione and isochroman-1,3-dione under microwave irradiation condition gave corresponding condensation products 2a,b; 3a,b; 4a,b and 5a,b, respectively, in good yields. Microwave-assisted condensation of 4-amino-N-(thiazol-2-yl)benzenesulfonamide (6a), 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (6b) and 4-amino-N-(4-methyl pyrimidin-2-yl)benzenesulfonamide (6c) with furan-2,5-dione, hexahydroisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione and isochroman-1,3-dione gave corresponding condensation products 7a–c, 8a–c, 9a–c and 10a–c, respectively, in good yields. All these compounds, i.e., 2a,b; 3a,b; 4a,b; 5a,b; 7a–c; 8a–c; 9a–c and 10a–c, were screened for in vitro anticancer activity against five human cancer cell lines, i.e., breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1) and liver (Hep G2). Compounds 7c and 9c exhibited good anticancer activity against ovary (PA-1) (IC50 value 8.12 ± 1.83 µM) and liver (Hep G2) (IC50 value 4 ± 1.9 µM) cancer cell lines, respectively.
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页码：3760 / 3771
页数：11
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