Recurrent Intramural Hematoma of the Small Intestine in a Severe Hemophilia A Patient with a High Titer of Factor VIII Inhibitor: A Case Report and Review of the Literature

被引：0
作者：
Akira Katsumi
Tadashi Matsushita
Kanji Hirashima
Toshihiro Iwasaki
Tatsuya Adachi
Koji Yamamoto
Tetsuhito Kojima
Junki Takamatsu
Hidehiko Saito
Tomoki Naoe
机构：
[1] Nagoya University Graduate School of Medicine,Department of Hematology and Oncology
[2] Nagoya University Hospital,Department of Blood Transfusion Service
[3] Nagoya University School of Health Sciences,Department of Medical Technology
[4] Nagoya Medical Center,undefined
来源：
International Journal of Hematology | 2006年 / 84卷
关键词：
Hemophilia A; Inhibitor; Intramural hematoma; Small intestine; Activated prothrombin complex concentrate;
D O I：
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中图分类号：
学科分类号：
摘要：
A 17-year-old man with severe hemophilia A (factor VIII <1%) developed intermittent left upper quadrant pain. He had a high titer of factor VIII inhibitor (1024 Bethesda units/mL) and was diagnosed with intramural hematoma of the jejunum. He was managed conservatively with activated prothrombin complex concentrate (APCC), resulting in the resolution of symptoms. He developed recurrent intramural hematoma of the small intestine over the next 54 months, and was successfully treated with APCC. This case highlights a rare clinical manifestation in hemophilia patients, and also indicates the effectiveness of APCC instead of exploratory surgery for intramural hematoma. Cases of intramural hematoma of the gastrointestinal tract among hemophilia patients are also reviewed.
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页码：166 / 169
页数：3
相关论文
共 98 条
[1]  
Mittal R(1985)Patterns of gastrointestinal hemorrhage in hemophilia Gastroenterology 88 515-522
[2]  
Spero JA(1997)Factor VIII inhibitors Thromb Haemost 78 641-646
[3]  
Lewis JH(2002)Inhibitor development in previously untreated patients with hemophilia A: a prospective long-term follow-up comparing plasma-derived and recombinant products Semin Thromb Hemost 28 285-290
[4]  
Gilles JG(2000)Inhibitors in young boys with haemophilia Baillieres Best Pract Res Clin Haematol 13 457-468
[5]  
Jacquemin MG(2002)First and second generation recombinant factor VIII concentrates in previously untreated patients: recovery, safety, efficacy, and inhibitor development Semin Thromb Hemost 28 273-276
[6]  
Saint-Remy JM(1999)Incidence of inhibitors in haemophilia A patients—a review of recent studies of recombinant and plasma-derived factor VIII concentrates Haemophilia 5 145-154
[7]  
Kreuz W(1973)Gastrointestinal bleeding in haemophilia Q J Med 42 503-511
[8]  
Ettingshausen CE(1994)Gastrointestinal bleeding in hemophilia as a complication of the use of over the counter non-steroidal anti-inflammatory drugs Am J Hematol 47 336-337
[9]  
Zyschka A(2005)Acute intestinal obstruction due to intramural haemorrhage in small intestine in a patient with severe haemophilia A and inhibitor Eur J Haematol 75 164-166
[10]  
Lusher JM(1964)Intramural intestinal hemorrhage Am J Roentgenol Radium Ther Nucl Med 92 1061-1071
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