This article describes the synthesis and characterization of three new Ru(II) polypyridyl complexes including [Ru(phen)2(dpphz)]2+ (1), [Ru(bpy)2(dpphz)]2+ (2) and [Ru(dmb)2(dpphz)]2+ (3) where dpphz = dipyrido[3,2-a:2′,3′-c] phenazine-11-hydrazide, phen =1,10-phenanthroline, bpy = 2,2′-bipyridine and dmb = 4,4′-dimethyl2,2′-bipyridine. The binding behaviors of these complexes to calf thymus DNA (CT-DNA) were explored by spectroscopic titrations, viscosity measurements. Results suggest that these complexes can bind to CT-DNA through intercalation. However, their binding strength differs from each other; this may be attributed to difference in the ancillary ligand. The cytotoxicity of 1–3 was evaluated by MTT assay; results indicated that all complexes have significant dose dependent cytotoxicity with HeLa tumor cell line. All complexes exhibited efficient photocleavage of pBR322 DNA upon irradiation. The DNA binding ability of 1–3 was also studied by docking the complexes into B-DNA using docking program.
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Liu, Yun-Jun
Liang, Zhen-Hua
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Liang, Zhen-Hua
Li, Zheng-Zheng
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Li, Zheng-Zheng
Yao, Jun-Hua
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Sun Yat Sen Univ, Instrumentat Anal & Res Ctr, Guangzhou 510275, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Yao, Jun-Hua
Huang, Hong-Liang
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Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
机构:
Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Xie, Yang-Yin
Huang, Hong-Liang
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Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Huang, Hong-Liang
Yao, Jun-Hua
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Sun Yat Sen Univ, Instrumentat Anal & Res Ctr, Guangzhou 510275, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Yao, Jun-Hua
Lin, Gan-Jian
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Lin, Gan-Jian
Jiang, Guang-Bin
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Jiang, Guang-Bin
Liu, Yun-Jun
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
机构:Zhongshan University,The Key Laboratory of Gene Engineering of Ministry of Education/State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry
Qian-Ling Zhang
Hong Xu
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机构:Zhongshan University,The Key Laboratory of Gene Engineering of Ministry of Education/State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry
Hong Xu
Hong Li
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机构:Zhongshan University,The Key Laboratory of Gene Engineering of Ministry of Education/State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry
Hong Li
Jie Liu
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机构:Zhongshan University,The Key Laboratory of Gene Engineering of Ministry of Education/State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry
Jie Liu
Jian-Zhong Liu
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机构:Zhongshan University,The Key Laboratory of Gene Engineering of Ministry of Education/State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry
Jian-Zhong Liu
Liang-Nian Ji
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机构:Zhongshan University,The Key Laboratory of Gene Engineering of Ministry of Education/State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry
Liang-Nian Ji
Jin-Gang Liu
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机构:Zhongshan University,The Key Laboratory of Gene Engineering of Ministry of Education/State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Tang, Bing
Shen, Fang
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South China Agr Univ, Dept Appl Chem, Guangzhou 510642, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Shen, Fang
Wan, Dan
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Wan, Dan
Guo, Bo-Hong
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Guo, Bo-Hong
Wang, Yang-Jie
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Wang, Yang-Jie
Yi, Qiao-Yan
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Yi, Qiao-Yan
Liu, Yun-Jun
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Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China
Guangdong Cosmet Engn & Technol Res Ctr, Guangzhou 510006, Guangdong, Peoples R ChinaGuangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China