Studies on Photocleavage, DNA Binding, Cytotoxicity, and Docking Studies of Ruthenium(II) Mixed Ligand Complexes

被引:0
|
作者
Yata Praveen Kumar
C. Shobha Devi
A. Srishailam
N. Deepika
V. Ravi Kumar
P. Venkat Reddy
K Nagasuryaprasad
Surya S. Singh
Penumaka Nagababu
S. Satyanarayana
机构
[1] Osmania University,Department of Chemistry
[2] University of Hyderabad,School of Chemistry
[3] National Dong Hwa University,Department of Chemistry
[4] Osmania University,Department of Biochemistry
[5] CSIR−Indian Institute of Chemical Technology,Inorganic & Physical Chemistry Division
来源
Journal of Fluorescence | 2016年 / 26卷
关键词
Polypyridyl hydrazide ligand; Ru(II) complexes; DNA-binding; Anticancer activity; Photocleavage; Docking studies;
D O I
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中图分类号
学科分类号
摘要
This article describes the synthesis and characterization of three new Ru(II) polypyridyl complexes including [Ru(phen)2(dpphz)]2+ (1), [Ru(bpy)2(dpphz)]2+ (2) and [Ru(dmb)2(dpphz)]2+ (3) where dpphz = dipyrido[3,2-a:2′,3′-c] phenazine-11-hydrazide, phen =1,10-phenanthroline, bpy = 2,2′-bipyridine and dmb = 4,4′-dimethyl2,2′-bipyridine. The binding behaviors of these complexes to calf thymus DNA (CT-DNA) were explored by spectroscopic titrations, viscosity measurements. Results suggest that these complexes can bind to CT-DNA through intercalation. However, their binding strength differs from each other; this may be attributed to difference in the ancillary ligand. The cytotoxicity of 1–3 was evaluated by MTT assay; results indicated that all complexes have significant dose dependent cytotoxicity with HeLa tumor cell line. All complexes exhibited efficient photocleavage of pBR322 DNA upon irradiation. The DNA binding ability of 1–3 was also studied by docking the complexes into B-DNA using docking program.
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页码:2119 / 2132
页数:13
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