Synthesis of N-methylmorpholinium 6-methyl-4-(2-thienyl)-5-phenylcarbamoyl-3-cyano-1,4-dihydropyridine-2-thiolate and its reaction with various functionally substituted methyl halides

被引:0
作者
Dyachenko V.D. [1 ]
Krivokolysko S.G. [1 ]
Litvinov V.P. [1 ]
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关键词
Methyl; Organic Chemistry; Aldehyde; Thiophene; Halide;
D O I
10.1007/BF02291942
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摘要
Condensation of the anilide of acetoacetic acid, thiophene aldehyde, cyanothioacetamide and N-methylmorpholine gave N-methylmorpholinium 6-methyl-4-(2-thienyl)-5-phenylcarbamoyl-3-cyano-1,4-dihydropyridine-2-thiolate which reacted with various halides ZCH2Hal or H2NCOCH(Ph)Cl to give substituted 2-ZCH2-thio or 2-H2NCOCH(Ph)-thio-1,4-dihydropyridines. ©1997 Plenum Publishing Corporation.
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页码:577 / 582
页数:5
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[1]  
Kastron, V.V., Vitolinya, R.O., Dubur, G.Ya., (1990) Khim-Farm. Zh., 6, p. 14