Family, twin, and adoption studies of bipolar disease.

被引：52
作者：
Taylor L. [1 ]
Faraone S.V. [1 ]
Tsuang M.T. [1 ]
机构：
[1] Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, 74 Fenwood Road, Boston, 02115, MA
来源：
Current Psychiatry Reports | 2002年 / 4卷 / 2期
关键词：
Psychotic Symptom; Bipolar Patient; Bipolar Affective Disorder; Adoption Study; Bipolar Disease;
D O I：
10.1007/s11920-002-0046-1
中图分类号：
学科分类号：
摘要：
Bipolar disease features states of severe depression that usually fluctuate with at least one episode of intense elation or mania. It is a disorder that has been thought for some time to have a heritable component. The lifetime prevalence of bipolar disease in the general population is approximately 1%. In contrast, family studies have shown the approximate lifetime risk of a first-degree relative of a bipolar proband to be 5% to 10%. Moreover, studies of monozygotic twins show that their risk of contracting the disease is as much as 75 times greater than that for the general population. In addition, adoption studies have demonstrated that biological relatives of bipolar patients are substantially more likely to have the disorder than are adoptive relatives.
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页码：130 / 133
页数：3
相关论文
共 68 条
[1]  
Craddock N(1999)The genetics of bipolar disorder J Med Genet 88 585-594
[2]  
Jones I(2000)Genetics of bipolar affective disorder Curr Psychiatry Rep 2 147-157
[3]  
Nurnberger JJ(1994)Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results form the national comorbidity survey Arch Gen Psychiatry 51 8-19
[4]  
Foroud T(2000)Parsing the association between bipolar, conduct, and substance use disorders: a familial risk analysis Biol Psychiatry 48 1037-1044
[5]  
Kessler RC(2000)Suicidality in bipolar compared to unipolar depressed inpatients Eur Arch Psychiatry Clin Neurosci 250 257-261
[6]  
McGonagle KA(2000)Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships Am J Psychiatry 157 2048-2050
[7]  
Biederman JS(2001)Molecular genetics of bipolar disorder Br J Psychiatry 178 128-133
[8]  
Faraone V(2000)Evaluating the parent-of-origin effect in bipolar affective disorder. Is a more penetrant subtype transmitted paternally J Affect Disord 59 183-192
[9]  
Bottlender R(2001)Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study Biol Psychiatry 49 405-409
[10]  
Jager M(2000)Prevalence and description of psychotic features in bipolar mania Curr Psychiatry Rep 2 286-290
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