Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar

被引：10

作者：

Andrianaivoarimanana V. ^{[1
,2
]}

Rajerison M. ^{[1
]}

Jambou R. ^{[2
,3
]}

机构：

[1] Unité Peste, Institut Pasteur de Madagascar, P.O. Box 1274, Ambatofotsikely, Antananarivo

[2] Unité d'Immunologie, Institut Pasteur de Madagascar, P.O. Box 1274, Ambatofotsikely, Antananarivo

[3] Department of Parasites and Insect Vectors, Pasteur Institute, 28 rue Dr Roux, Paris

来源：

BMC Research Notes | / 11卷 / 1期

关键词：

F1; antigen; Madagascar; Outbreak; Plague; Rattus rattus;

D O I：

10.1186/s13104-018-3984-3

中图分类号：

学科分类号：

摘要：

Objectives: In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. We investigate the hypothesis that lineages of rats can acquire resistance to plague and that previous contacts with the bacteria will affect their survival, allowing maintenance of infected fleas. For this purpose, laboratory-born rats were obtained from wild black rats originating either from plague-endemic or plague-free zones, and were challenged with Y. pestis. Survival rate and antibody immune responses were analyzed. Results: Inoculation of low doses of Y. pestis greatly increase survival of rats to subsequent challenge with a lethal dose. During challenge, cytokine profiles support activation of specific immune response associated with the bacteria control. In addition, F1 rats from endemic areas exhibited higher survival rates than those from non-endemic ones, suggesting a selection of a resistant lineage. In Madagascar, these results support the role of black rat as long term reservoir of infected fleas supporting maintenance of plague transmission. © 2018 The Author(s).

引用

共 31 条

[1]

Gage K.L., Kosoy M.Y., Natural history of plague: Perspectives from more than a century of research, Annu Rev Entomol, 50, pp. 505-528, (2005)

[2]

Quan T.J., Barnes A.M., Carter L.G., Tsuchiya K.R., Experimental plague in rock squirrels, Spermophilus variegatus (Erxleben), J Wildl Dis, 21, pp. 205-210, (1985)

[3]

Thomas R.E., Barnes A.M., Quan T.J., Beard M.L., Carter L.G., Hopla C.E., Susceptibility to Yersinia pestis in the northern grasshopper mouse (Onychomys leucogaster), J Wildl Dis, 24, pp. 327-333, (1988)

[4]

Hubbert W.T., Goldenberg M.I., Natural resistance to plague: Genetic basis in the vole (Microtus californicus), Am J Trop Med Hyg, 19, pp. 1015-1019, (1970)

[5]

Shepherd A.J., Leman P.A., Hummitzsch D.E., Experimental plague infection in South African wild rodents, J Hyg (Lond)., 96, pp. 171-183, (1986)

[6]

Rahalison L., Ranjalahy M., Duplantier J.M., Duchemin J.B., Ravelosaona J., Ratsifasoamanana L., Et al., Susceptibility to plague of the rodents in Antananarivo, Madagascar, Adv Exp Med Biol., 529, pp. 439-442, (2003)

[7]

Tollenaere C., Rahalison L., Ranjalahy M., Duplantier J.M., Rahelinirina S., Telfer S., Et al., Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar, Eco Health, 7, pp. 242-247, (2010)

[8]

Brygoo E.R., Epidémiologie de la peste à Madagascar, Arch Inst Pasteur Madagascar, 35, pp. 9-147, (1966)

[9]

Plague around the world, 2010-2015, Wkly Epidemiol Rec, 91, pp. 89-93, (2016)

[10]

Tollenaere C., Rahalison L., Ranjalahy M., Rahelinirina S., Duplantier J.M., Brouat C., CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar, Infect Genet Evol., 8, pp. 891-897, (2008)

← 1 2 3 4 →