New insights into M1/M2 macrophages: key modulators in cancer progression

被引：0
作者：
Jiuyang Liu
Xiafei Geng
Jinxuan Hou
Gaosong Wu
机构：
[1] Zhongnan Hospital of Wuhan University,Department of Thyroid and Breast Surgery
[2] Hubei Cancer Hospital,Department of Ultrasound Imaging
来源：
Cancer Cell International | / 21卷
关键词：
Tumor-associated macrophages; Cancer; Metastasis; Polarization;
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摘要：
Infiltration of macrophages in and around tumor nest represents one of the most crucial hallmarks during tumor progression. The mutual interactions with tumor cells and stromal microenvironment contribute to phenotypically polarization of tumor associated macrophages. Macrophages consist of at least two subgroups, M1 and M2. M1 phenotype macrophages are tumor-resistant due to intrinsic phagocytosis and enhanced antitumor inflammatory reactions. Contrastingly, M2 are endowed with a repertoire of tumor-promoting capabilities involving immuno-suppression, angiogenesis and neovascularization, as well as stromal activation and remodeling. The functional signature of M2 incorporates location-related, mutually connected, and cascade-like reactions, thereby accelerating paces of tumor aggressiveness and metastasis. In this review, mechanisms underlying the distinct functional characterization of M1 and M2 macrophages are demonstrated to make sense of M1 and M2 as key regulators during cancer progression.
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