An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression

被引:0
作者
Yufeng Qin
John D. Roberts
Sara A. Grimm
Fred B. Lih
Leesa J. Deterding
Ruifang Li
Kaliopi Chrysovergis
Paul A. Wade
机构
[1] Eukaryotic Transcriptional Regulation Group,
[2] Epigenetics and Stem Cell Biology Laboratory,undefined
[3] National Institute of Environmental Health Sciences,undefined
[4] Integrative Bioinformatics Group,undefined
[5] Epigenetics and Stem Cell Biology Laboratory,undefined
[6] National Institute of Environmental Health Sciences,undefined
[7] Mass Spectrometry Research & Support Group,undefined
[8] Epigenetics and Stem Cell Biology Laboratory,undefined
[9] National Institute of Environmental Health Sciences,undefined
来源
Genome Biology | / 19卷
关键词
Microbiome; Obesity; Cancer; Colorectal cancer; Epigenetics; Transcription factor; Gene expression; Histone methylation; Histone acetylation;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 285 条
[1]  
Feil R(2012)Epigenetics and the environment: emerging patterns and implications Nat Rev Genet 13 97-109
[2]  
Fraga MF(2015)Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression Epigenetics 10 861-71
[3]  
Terashima M(2016)Diet-microbiota interactions mediate global epigenetic programming in multiple host tissues Mol Cell 64 982-92
[4]  
Barbour S(2000)Obesity as a medical problem Nature 404 635-43
[5]  
Ren J(2016)The intestinal immune system in obesity and insulin resistance Cell Metab 23 413-26
[6]  
Yu W(2012)Host-gut microbiota metabolic interactions Science 336 1262-7
[7]  
Han Y(2014)The gut microbiome and the brain J Med Food 17 1261-72
[8]  
Muegge K(2014)The gut microbiota, bacterial metabolites and colorectal cancer Nat Rev Microbiol 12 661-72
[9]  
Krautkramer KA(2014)Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape Genome Res 24 1504-16
[10]  
Kreznar JH(2011)The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon Cell Metab 13 517-26