Pathogenesis of Henoch-Schönlein purpura nephritis

被引：0
作者：
Keith K. Lau
Hitoshi Suzuki
Jan Novak
Robert J. Wyatt
机构：
[1] McMaster University,Department of Pediatrics
[2] University of Alabama at Birmingham,Department of Microbiology
[3] Juntendo University School of Medicine,Department of Nephrology
[4] Children’s Foundation Research Center at the Le Bonheur Children’s Medical Center,Division of Pediatric Nephrology
[5] University of Tennessee Health Sciences Center,undefined
来源：
Pediatric Nephrology | 2010年 / 25卷
关键词：
Henoch-Schönlein purpura nephritis; Children; Galactose-deficient IgA1; Pathogenesis; Immune complex;
D O I：
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中图分类号：
学科分类号：
摘要：
The severity of renal involvement is the major factor determining the long-term outcome of children with Henoch-Schönlein purpura (HSP) nephritis (HSPN). Approximately 40% children with HSP develop nephritis, usually within 4 to 6 weeks after the initial onset of the typical purpuric rashes. Although the pathogenetic mechanisms are still not fully delineated, several studies suggest that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, leading to the formation of the circulating immune complexes and their mesangial deposition that induce renal injury in HSPN.
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页码：19 / 26
页数：7
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