Subcellular spatial regulation of canonical Wnt signalling at the primary cilium

被引：0
作者：
Madeline A. Lancaster
Jana Schroth
Joseph G. Gleeson
机构：
[1] Laboratory for Neurogenetics,Department of Neurosciences
[2] Howard Hughes Medical Institute,undefined
[3] Biomedical Sciences Program,undefined
[4] LBR 3A16,undefined
[5] 9500 Gilman Drive,undefined
[6] University of California,undefined
[7] Present address: IMBA—Institute of Molecular Biotechnology of the Austrian Academy of Science,undefined
[8] Vienna 1030,undefined
[9] Austria,undefined
来源：
Nature Cell Biology | 2011年 / 13卷
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摘要：
Through the action of intraflagella transport, primary cilia are found to sequester Jouberin, a positive regulator of Wnt signalling, to limit β-catenin nuclear entry and to modulate Wnt responsiveness. Consequently, Wnt is exacerbated in cells without cilia but inhibited in cells with more than one cilium.
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页码：700 / 707
页数：7
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