Basaloid squamous cell carcinoma of the head and neck: A Clinicopathological and Follow-Up Study of 40 Cases and Review of the Literature

被引：51

作者：

Ereño C. ^{[1
]}

Gaafar A. ^{[1
]}

Garmendia M. ^{[1
]}

Etxezarraga C. ^{[1
]}

Bilbao F.J. ^{[1
]}

López J.I. ^{[2
]}

机构：

[1] Department of Pathology, Hospital de Basurto, Basque Country University, Bilbao 48013

[2] Department of Pathology, Hospital de Cruces, Barakaldo, Basque Country University (EHU/UPV), Bizkaia

来源：

Head and Neck Pathology | 2008年 / 2卷 / 2期

关键词：

Basaloid-squamous cell carcinoma; Differential diagnosis; Head and neck; Hypopharynx; Larynx; Metastasis; Oral cavity; Oropharynx; Prognosis; Recurrence;

D O I：

10.1007/s12105-008-0045-6

中图分类号：

学科分类号：

摘要：

Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of cancer that mainly arises in the upper aerodigestive tract. This study reviews the clinicopathological features and follow-up of a series of cases occurring in the head and neck. During a 32-year period (1974-2005), a total of 40BSCCs have been diagnosed in the head and neck in our Institution. Males predominated in the series (35M/5F). The average age was 60.2 years (range, 40-85). Tobacco and alcohol consumption was found in more than 80% of the cases. Topographic distribution was as follows: larynx and hypopharynx, 22 cases (55%); oropharynx, 12 cases (30%); and oral cavity 6 cases (15%). The basaloid component predominated in 29 cases (72.5%). Vasculolymphatic invasion was detected in 5 cases (12.5%). Lymph node metastases were seen in 25 cases (62.5%, levels II and III in the neck dissection). Local recurrences appeared in 11 cases (27.5%) and distant metastases in 6 (15%). In 7 cases (17.5%) a second primary tumour was detected. The 2002 TNM staging was as follows: Stage I, 5 cases (12.5%); Stage II, 7 cases (17.5%); Stage III, 8 cases (20%), and Stage IV, 20 cases (50%). On follow-up, 21 cases (52.5%) are alive and 19 (47.5%) died of disease. Three- and 5-year overall survival was 50% and 38.5%, respectively. A significant shorter survival was detected in node positive patients (P<0.05). © Humana 2008.

引用

页码：83 / 91

页数：8

共 44 条

[1]

Wain S.L., Kier R., Wollmer R.T., Et al., Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: Report of 10 cases, Hum Pathol., 17, pp. 1158-1166, (1986)

[2]

Banks E.R., Frierson Jr. H.F., Mills S.E., Et al., Basaloid squamous cell carcinoma of the head and neck. A clinicopathologic and immunohistochemical study of 40 cases, Am J Surg Pathol., 16, pp. 939-946, (1992)

[3]

Barnes L., Basaliod squamous cell carcinoma, Surgical pathology of the head and neck, pp. 184-189, (2001)

[4]

Luna M.A., El Naggar A., Parichatikanond P., Et al., Basaloid squamous carcinoma of the upper aeorodigestive tract. Clinicopathologic and DNA flow cytometric analysis, Cancer., 66, pp. 537-542, (1990)

[5]

Paulino A.F.G., Singh B., Shah J.P., Et al., Basaloid squamous cell carcinoma of the head and neck, Laryngoscope., 110, pp. 1479-1482, (2000)

[6]

Hellquist H.B., Dahl F., Karlsson M.G., Et al., Basaloid squamous cell carcinoma of the palate, Histopathology., 25, pp. 178-180, (1994)

[7]

Coppola D., Catalano E., Tang C.K., Et al., Basaloid squamous cell carcinoma of the floor of the mouth, Cancer., 72, pp. 2299-2305, (1993)

[8]

Ide F., Shimoyama T., Horie N., Et al., Basaloid squamous cell carcinoma of the oral mucosa: A new cases and review of 45 cases in the literature, Oral Oncol., 38, pp. 120-124, (2002)

[9]

Wieneke J.A., Thompson L.D., Wenig B.M., Basaloid squamous cell carcinoma of the sinonasal tract, Cancer., 85, pp. 841-854, (1999)

[10]

Wan S.K., Chan J.K.C., Lau W.H., Et al., Basaloid-squamous carcinoma of the nasopharynx. An Epstein-Barr virus-associated neoplasm compared with morphologically identical tumors occurring in other sites, Cancer., 76, pp. 1689-1693, (1995)

← 1 2 3 4 5 →