Chiral Separation of Four Piperidinic Benzoxazolinone Compounds by CE and LC

Capillary electrophoresis with negatively charged cyclodextrins and high performance liquid chromatography on polysaccharide chiral stationary phases have been explored for the enantioseparation of chiral piperidinic benzoxazolinone compounds. Operational parameters such as the nature and the concentration of the chiral selectors in CE and the nature of the polysaccharide stationary phase and the composition of the mobile phase in LC were varied in order to achieve the separation of the all four concerning compounds. Limits of detection and quantification of both methods were evaluated under the optimal conditions.