Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway

被引：0
作者：
Jung Min Ha
Seung Hoon Baek
Young Hwan Kim
Seo Yeon Jin
Hye Sun Lee
Sun Ja Kim
Hwa Kyoung Shin
Dong Hyung Lee
Sang Heon Song
Chi Dae Kim
Sun Sik Bae
机构：
[1] Gene and Cell Therapy Center for Vessel-Associated Disease,Department of Pharmacology
[2] Medical Research Institute,Department of Anesthesia and Pain Medicine
[3] Pusan National University School of Medicine,Department of Physics
[4] Pusan National University Hospital,Department of Anatomy
[5] Dong-A University,Department of Obstetrics and Gynecology
[6] Pusan National University of Korean Medicine,Department of Internal Medicine
[7] Pusan National University Hospital,undefined
[8] Pusan National University Hospital,undefined
来源：
Experimental & Molecular Medicine | 2016年 / 48卷
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摘要：
Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein endothelial cells (HUVECs) significantly delayed proliferation, migration and capillary-like tube formation. In addition, mice lacking PLC-β3 showed impaired retinal angiogenesis with delayed endothelial proliferation, reduced endothelial cell activation, abnormal vessel formation and hemorrhage. Finally, tumor formation was significantly reduced in mice lacking PLC-β3 and showed irregular size and shape of blood vessels. These results suggest that regulation of endothelial function by PLC-β3 may contribute to angiogenesis.
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页码：e240 / e240
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