An unusual case of hypothermia associated with therapeutic doses of olanzapine: A case report

被引：10

作者：

Rasnayake L.R.M.R. ^{[1
]}

Wimalarathne H. ^{[1
]}

Jayapala R.K.T.D.P. ^{[1
]}

Gamage C.D.M. ^{[1
]}

Dassanayake D.L.B. ^{[1
]}

Ratnayake S.L. ^{[1
]}

Colombage A. ^{[1
]}

Nandadeva D. ^{[1
]}

Nelumdeniya A.N.P.K. ^{[1
]}

机构：

[1] Medical Unit, Teaching Hospital, Kandy

来源：

Journal of Medical Case Reports | / 5卷 / 1期

关键词：

Schizophrenia; Clozapine; Risperidone; Olanzapine; Antipsychotic Drug;

D O I：

10.1186/1752-1947-5-189

中图分类号：

学科分类号：

摘要：

Introduction. We report a case of a 42-year-old man who had symptomatic hypothermia as a result of taking olanzapine for paranoid schizophrenia. According to published data, only a few cases of hypothermia associated with olanzapine have been reported since its introduction into clinical use. Case presentation. A 42-year-old Sri Lankan man with schizophrenia who was being treated with a therapeutic dose of olanzapine presented with reduced level of consciousness. He had a core temperature of 32°C and was bradycardic. At the time of admission, the electrocardiogram showed sinus bradycardia with J waves. He did not have any risk factors for developing hypothermia except the use of olanzapine. There was improvement in his clinical condition with reversal of electrocardiogram changes following gradual rewarming and the omission of olanzapine. Conclusion: Hypothermia induced by antipsychotic medications is not uncommon, but olanzapine-induced hypothermia is rare and occurrence has been reported during initiation or increasing the dose. But here the patient developed hypothermia without dose adjustment. © 2011 Rasnayake et al; licensee BioMed Central Ltd.

引用

共 12 条

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