Relations Between Pathological Markers and Radioiodine Scan and 18F-FDG PET/CT Findings in Papillary Thyroid Cancer Patients With Recurrent Cervical Nodal Metastases

被引：9
作者：
Lee J.W. [1 ]
Min H.S. [2 ]
Lee S.M. [3 ]
Kwon H.W. [4 ]
Chung J.-K. [4 ,5 ]
机构：
[1] Department of Nuclear Medicine, Catholic Kwandong University International St. Mary’s Hospital, Seoul
[2] Department of Pathology, Seoul National University Hospital, Seoul
[3] Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan
[4] Department of Nuclear Medicine, Seoul National University College of Medicine, Medicine, 101 Daehang-Ro, Jongno-Gu, Seoul
[5] Cancer Research Institute, Seoul National University College of Medicine, Seoul
来源：
Nuclear Medicine and Molecular Imaging | 2015年 / 49卷 / 2期
关键词：
!sup]18[!/sup]F-fluorodeoxyglucose; Positron emission tomography; Radioiodine; Thyroid cancer;
D O I：
10.1007/s13139-015-0324-6
中图分类号：
学科分类号：
摘要：
Purpose: The aim of this study was to investigate relationships between the immunohistochemical results and radioiodine scan and 18F-FDG PET findings in papillary thyroid cancer (PTC) patients with recurrent cervical nodal metastases. Methods: A total of 46 PTC patients who had undergone a radioiodine scan and/or 18F-FDG PET/CT and a subsequent operation on recurrent cervical lymph nodes were enrolled. Twenty-seven patients underwent 18F-FDG PET/CT, 8 underwent radioiodine scans, and 11 underwent both scans. In all surgical specimens, the immunoexpressions of thyroglobulin (Tg), sodium-iodide symporter (NIS), glucose transporter 1 (Glut-1), and somatostatin receptor 1 and 2A (SSTR1 and SSTR2A) were assessed, and associations between these expressions and radioiodine scan and 18F-FDG PET findings were evaluated. Results: Of the 38 patients who underwent 18F-FDG PET/CT, all patients with weak Tg expression had positive 18F-FDG uptake, while only 45 % of the patients with moderate or strong Tg expression showed positive uptake (p = 0.01). The proportion of patients with positive 18F-FDG uptake increased as the degree of Glut-1 expression with luminal accentuation increased. Of the 19 patients who underwent a radioiodine scan, the proportion with positive radioiodine uptake was greater among patients with strong NIS and SSTR2A expression than among patients expressing these markers at weak levels (p = 0.04 for all). All three patients with weak Tg expression were negative for radioiodine uptake. Conclusion: The 18F-FDG uptakes of recurrent cervical nodes are related to strong Glut-1 expression with luminal accentuation and weak Tg expression, whereas radioiodine uptake is related to the strong expressions of NIS and SSTR2A. © 2015, Korean Society of Nuclear Medicine.
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页码：127 / 134
页数：7
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