Transforming Growth Factor Beta (TGF-β1) Induces Pro-Reparative Phenotypic Changes in Epicardial Cells in Mice

被引：0

作者：

K. V. Dergilev

Z. I. Tsokolaeva

I. B. Beloglazova

E. I. Ratner

E. V. Parfenova

机构：

[1] Laboratory of Angiogenesis,

[2] Institute of Experimental Cardiology,undefined

[3] National Medical Research Centre of Cardiology,undefined

[4] Ministry of Health of the Russian Federation,undefined

[5] V. A. Negovsky Research Institute of General Reanimatology,undefined

[6] Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology,undefined

[7] Laboratory of Postgenomic Technologies in Medicine,undefined

[8] Faculty of Fundamental Medicine,undefined

[9] M. V. Lomonosov Moscow State University,undefined

来源：

Bulletin of Experimental Biology and Medicine | 2021年 / 170卷

关键词：

epicardial cells; transforming growth factor beta; myocardial infarction; epithelial-mesenchymal transition; heart repair;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We evaluated the content of active form of TGF-β1 in the intact and post-infarction heart and the effect of this factor on the properties of epicardial cells. During the acute stage after myocardial infarction, the production of TGF-β1 in the heart increased, which closely correlated with activation of epicardial cells (appearance of a pool of Wt1+ epicardial cells entering the epithelial-mesenchymal transition). The role of TGF-β1 as the factor of epicardial activation was confirmed by the results of in vitro experiments: addition of recombinant TGF-β1 to cultured epicardial cells led to enhanced expression of genes of epithelial-mesenchymal transition and phenotypic transformation of these cells leading to the appearance of cells with markers of smooth muscle cells and fibroblasts. Our findings suggest that the regulatory axis “TGF-β1—epicardium cells” can be considered as an important link of the post-infarction reparative process and adaptive response during heart remodeling after myocardial infarction and as the target for therapeutic interventions.

引用

页码：565 / 570

页数：5

共 119 条

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