Towards transgenic primates: What can we learn from mouse genetics?

被引：0
作者：
Hui Kuang
Phillip L. Wang
Joe Z. Tsien
机构：
[1] Medical College of Georgia,Brain and Behavior Discovery Institute, School of Medicine
[2] East China Normal University,Yunnan Banna Primate Disease Model Research Center, and Shanghai Institute of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics, MOE & STCSM
来源：
Science in China Series C: Life Sciences | 2009年 / 52卷
关键词：
Non-human primate; Mouse; Transgene; Genetics; Learning; Memory; disease model;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.
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页码：506 / 514
页数：8
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