Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation

被引：0

作者：

Martina Minnich

Hiromi Tagoh

Peter Bönelt

Elin Axelsson

Maria Fischer

Beatriz Cebolla

Alexander Tarakhovsky

Stephen L Nutt

Markus Jaritz

Meinrad Busslinger

机构：

[1] Research Institute of Molecular Pathology,Department of Medical Biology

[2] Vienna Biocenter,undefined

[3] Laboratory of Lymphocyte Signaling,undefined

[4] The Rockefeller University,undefined

[5] The Walter and Eliza Hall Institute of Medical Research,undefined

[6] The University of Melbourne,undefined

[7] Present address: Gregor Mendel Institute of Molecular Plant Biology,undefined

[8] Austrian Academy of Sciences,undefined

[9] Vienna,undefined

[10] Austria.,undefined

来源：

Nature Immunology | 2016年 / 17卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Blimp-1 is known to act as a transcriptional repressor by suppressing genes associated with mature and activated germinal center B cells. Busslinger and colleagues show that Blimp-1 can also directly activate gene expression in plasma cells, including those encoding proteins that regulate the production of membrane-bound immunoglobulin versus secreted immunoglobulin.

引用

页码：331 / 343

页数：12

共 50 条

[1] Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation
Minnich, Martina
Tagoh, Hirorni
Boenelt, Peter
Axelsson, Elin
Fischer, Maria
Cebolla, Beatriz
Tarakhovsky, Alexander
Nutt, Stephen L.
Jaritz, Markus
Busslinger, Meinrad
NATURE IMMUNOLOGY, 2016, 17 (03) : 331 - 343
[2] Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1
Kallies, Axel
Hasbold, Jhagvaral
Fairfax, Kirsten
Pridans, Clare
Emslie, Dianne
McKenzie, Brent S.
Lew, Andrew M.
Corcoran, Lynn M.
Hodgkin, Philip D.
Tarlinton, David M.
Nutt, Stephen L.
IMMUNITY, 2007, 26 (05) : 555 - 566
[3] Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1
John, Shinu A.
Clements, James L.
Russell, Lisa M.
Garrett-Sinha, Lee Ann
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (02) : 951 - 962
[4] SUMOylation of Blimp-1 is critical for plasma cell differentiation
Ying, Hsia-Yuan
Su, Shin-Tang
Hsu, Pang-Hung
Chang, Che-Chang
Lin, I-Ying
Tseng, Yu-Hsuan
Tsai, Ming-Daw
Shih, Hsiu-Ming
Lin, Kuo-I
EMBO REPORTS, 2012, 13 (07) : 631 - 637
[5] Differential involvement of the transcription factor Blimp-1 in T cell-independent and -dependent B cell differentiation to plasma cells
Soro, PG
Morales-A, P
Martínez-M, JA
Morales-A, S
Copín, SG
Marcos, MAR
Gaspar, ML
JOURNAL OF IMMUNOLOGY, 1999, 163 (02): : 611 - 617
[6] REGULATORY ROLE OF TRANSCRIPTION FACTOR BLIMP-1 IN SJOGREN'S SYNDROME
Wu, R.
Wang, L.
Zheng, X.
Wang, Y.
Wang, G.
Li, X.
Li, X.
ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 344 - 344
[7] The role of Blimp-1 in lymphocyte terminal differentiation and homeostasis
Kallies, A
Hawkins, ED
Belz, GT
Metcalf, D
Hommel, M
Corcoran, LM
Hodgkin, PD
Nutt, SL
TISSUE ANTIGENS, 2005, 66 (05): : 458 - 458
[8] Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6
Ochiai, Kyoko
Muto, Akihiko
Tanaka, Hiromu
Takahashi, Shinichiro
Igarashi, Kazuhiko
INTERNATIONAL IMMUNOLOGY, 2008, 20 (03) : 453 - 460
[9] ERKs Induce Expression of the Transcriptional Repressor Blimp-1 and Subsequent Plasma Cell Differentiation
Yasuda, Tomoharu
Kometani, Kohei
Takahashi, Noriko
Imai, Yuuki
Aiba, Yuichi
Kurosaki, Tomohiro
SCIENCE SIGNALING, 2011, 4 (169)
[10] Repression of c-myc transcription by blimp-1, an inducer of terminal B cell differentiation
Lin, Y
Wong, KK
Calame, K
SCIENCE, 1997, 276 (5312) : 596 - 599

← 1 2 3 4 5 →