Hsp90 at the crossroads of genetics and epigenetics

被引：0
作者：
Keith SK Wong
Walid A Houry
机构：
[1] University of Toronto,Department of Biochemistry
[2] 1 King's College Circle,undefined
[3] Medical Sciences Building,undefined
来源：
Cell Research | 2006年 / 16卷
关键词：
Hsp90; molecular chaperone; genetics; epigenetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hsp90 is a specialized molecular chaperone that is capable of buffering the expression of abnormal phenotypes. Inhibition of Hsp90 activity results in the expression of these phenotypes that are otherwise masked. Selection of offspring from the crossing of affected progenies results in inheritance and enrichment of these phenotypes, which can become independent of their original stimuli. The current combined evidence favours a model involving the interplay between genetics and epigenetics. The recent proteomics efforts to characterize the Hsp90 interaction networks provide further clues into the molecular mechanisms behind this complex phenomenon. This review summarizes the most recent experimental observations and briefly discusses the genetic and epigenetic views used in explaining the different observations.
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页码：742 / 749
页数：7
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