Endogenous Cannabinoid Anandamide Increases Heart Resistance to Arrhythmogenic Effects of Epinephrine: Role of CB1 and CB2 Receptors

被引：0

作者：

D. S. Ugdyzhekova

N. A. Bernatskaya

J. B. Stefano

V. F. Graier

S. W. Tam

R. Mekhoulam

机构：

[1] Tomsk State Pedagogical University,

[2] New York University,undefined

[3] Gratz University,undefined

[4] NitroMed Company,undefined

[5] Jewish Jerusalem University,undefined

来源：

Bulletin of Experimental Biology and Medicine | 2001年 / 131卷

关键词：

cannabinoid receptors; epinephrine; arrhythmias;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Intravenous injection of 10 mg/kg anandamide reduces the incidence and duration of epinephrine-induced arrhythmias in rats. SR141716A and SR144528, antagonists of cannabinoid receptor I and II did not abolish the antiarrhythmic effect of anandamide. These data suggest that the antiarrhythmic effect of anandamide is nonspecific or mediated via unknown cannabinoid receptors, but not associated with activation of cannabinoid receptors I and II.

引用

页码：251 / 253

页数：2

共 42 条

[1] Bilfinger T. V.(1998)undefined Int. J. Cardiol. 64 S15-S22
[2] Salzet M.(1999)undefined Mol. Pharmacol. 55 473-480
[3] Fimiani C.(1986)undefined J. Cardiovasc. Pharmacol. 8 S2-S9
[4] Bouaboula M.(1998)undefined Ann. Rev. Pharmacol. Toxicol. 38 179-200
[5] Desnoyer N.(1995)undefined Eur. J. Biochem. 232 54-61
[6] Carayon P.(1999)undefined Proc. Natl. Acad. Sci. USA 96 14,228-14,233
[7] Eisner D. A.(1984)undefined Clin. Exp. Pharmacol. Physiol. 11 81-85
[8] Felder C. C.(1992)undefined J. Am. Coll. Cardiol. 19 1622-1633
[9] Glass M.(1996)undefined Psychopharmacology 124 315-322
[10] Galiegue S.(1997)undefined Eur. J. Pharmacol. 335 205-209

← 1 2 3 4 5 →