Tuned thalamic excitation is amplified by visual cortical circuits

被引:0
作者
Anthony D Lien
Massimo Scanziani
机构
[1] Neurosciences Graduate Program,Neurobiology Section and Department of Neuroscience
[2] University of California San Diego,undefined
[3] Center for Neural Circuits and Behavior,undefined
[4] University of California San Diego,undefined
[5] Howard Hughes Medical Institute,undefined
[6] University of California San Diego,undefined
来源
Nature Neuroscience | 2013年 / 16卷
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摘要
Using optogenetics to silence the cortex, the authors show that thalamic inputs to layer 4 V1 neurons in anesthetized mice only contribute a third of the total excitation to these cells during presentation of visual stimuli. Moreover, they find that a small offset in the center of ON and OFF receptive subfields accounts for the orientation tuning of thalamic excitation to these cells.
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页码:1315 / 1323
页数:8
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[1]  
Nelson S(1994)Orientation selectivity of cortical neurons during intracellular blockade of inhibition Science 265 774-777
[2]  
Toth L(2000)Orientation tuning of input conductance, excitation and inhibition in cat primary visual cortex J. Neurophysiol. 84 909-926
[3]  
Sheth B(2010)Intervening inhibition underlies simple-cell receptive field structure in visual cortex Nat. Neurosci. 13 89-96
[4]  
Sur M(2011)Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells Neuron 71 542-554
[5]  
Anderson JS(2002)Dynamic representation of whisker deflection by synaptic potentials in spiny stellate and pyramidal cells in the barrels and septa of layer 4 rat somatosensory cortex J. Physiol. (Lond.) 543 49-70
[6]  
Carandini M(2007)Defining cortical frequency tuning with recurrent excitatory circuitry Nat. Neurosci. 10 1594-1600
[7]  
Ferster D(1962)Receptive fields, binocular interaction and functional architecture in the cat's visual cortex J. Physiol. (Lond.) 160 106-154
[8]  
Liu BH(1991)Relation of cortical cell orientation selectivity to alignment of receptive fields of the geniculocortical afferents that arborize within a single orientation column in ferret visual cortex J. Neurosci. 11 1347-1358
[9]  
Liu BH(2011)Population receptive fields of ON and OFF thalamic inputs to an orientation column in visual cortex Nat. Neurosci. 14 232-238
[10]  
Brecht M(1995)Specificity of monosynaptic connections from thalamus to visual cortex Nature 378 281-284