Consequences of CXCL10 and IL-6 induction by the murine IFN-α1 transgene in ocular herpes simplex virus type 1 infection

被引：0
作者：
Stephanie Wickham
John Ash
Thomas E. Lane
Daniel J. J. Carr
机构：
[1] The University of Oklahoma Health Sciences Center,Department of Ophthalmology, DMEI #415
[2] The University of Oklahoma Health Sciences Center,Department of Cell Biology
[3] The University of Oklahoma Health Sciences Center,Department of Microbiology
[4] The University of Oklahoma Health Sciences Center,Department of Immunology
[5] University of California,Department of Molecular Biology and Biochemistry
来源：
Immunologic Research | 2004年 / 30卷
关键词：
HSV-1; Chemokine; CXCL10; Type I interferon; Interleukin-6;
D O I：
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学科分类号：
摘要：
Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a “latent” infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of type I interferon transgenes has been found to antagonize viral replication and spread from the eye to the nervous system. Associated with the in situ transfection of the cornea is the upregulation of two inflammatory molecules, interleukin-6 and CXCL10. In this article, we will further examine the contribution these molecules may have in the host response to ocular infection with herpes simplex virus type 1.
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页码：191 / 200
页数：9
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  • [1] Carr DJJ(2003)Effect of anti-CXCL 10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection J Virol 77 10037-10046
  • [2] Chodosh J(1997)Delayed acute retinal necrosis after herpetic encephalitis Br J Ophthalmol 81 415-420
  • [3] Ash J(1999)Acute retinal necrosis after neonatal herpes encephalitis Br J Ophthalmol 83 123-124
  • [4] Lane TE(2001)Topical application of the cornea post-infection with plasmid DNA encoding interferon-α1 but not recombinant interferon-αA reduces herpes simplex virus type 1-induced mortality in mice J Neuroimmunol 121 49-58
  • [5] Pavesio CE(2002)The antiviral efficacy of the murine alpha-1 interferon transgene against ocular herpes simplex virus type 1 requires the presence of CD4 J Virol 76 9398-9406
  • [6] Conrad DK(2000), αβ T-cell receptor-positive T lymphocytes with the capacity to produce gamma interferon J Immunol 164 6435-6443
  • [7] Mccluskey PJ(1989)Plasmid DNA encoding IFN-α1 antagonizes herpes simplex virus type 1 ocular infection through CD4 Eur J Immunol 19 689-694
  • [8] Mitchel SM(1993) and CD8 Glia 9 41-47
  • [9] Towler HM(1994) T lymphocytes J Infect Dis 170 678-681
  • [10] Lightman S(2001)On the cellular source and function of interleukin-6 produced in the central nervous system in viral disease J Med Virol 63 252-258
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