NKG2D in NK and T Cell-Mediated Immunity

被引：0
作者：
Kouetsu Ogasawara
Lewis L. Lanier
机构：
[1] University of California,Department of Microbiology & Immunology and Cancer Research Institute
[2] International Medical Center of Japan,Department of Intractable Diseases, Division of Clinical Immunology, The Research Institute
[3] University of California,Department of Microbiology & Immunology and Cancer Research Institute
来源：
Journal of Clinical Immunology | 2005年 / 25卷
关键词：
NK cells; NKG2D; DAP10; RAE-1; MICA; autoimmunity; bone marrow transplantation; T cell;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on γδ-TcR+ T cells and αβ-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.
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页码：534 / 540
页数：6
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