Fiber-type-dependent expression of adenovirus-mediated transgene in mouse skeletal muscle fibers

被引：0
|
作者：
Y. Hagiwara
A. Ishii
Ikuya Nonaka
Tateki Kikuchi
Shin’ichi Takeda
机构：
[1] National Institute of Neuroscience,
[2] National Center of Neurology and Psychiatry (NCNP),undefined
[3] 4-1-1 Ogawa-Higashi,undefined
[4] Kodaira,undefined
[5] Tokyo 187,undefined
[6] Japan Tel.: +81-42-341-2711 (5224),undefined
[7] Fax: +81-42-346-1750,undefined
来源：
Acta Neuropathologica | 1998年 / 96卷
关键词：
Key words Mouse skeletal muscle; Adenovirus vector; lacZ gene; Myofiber type;
D O I：
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中图分类号：
学科分类号：
摘要：
We show the efficient transduction and expression of the lacZ gene in the skeletal muscle of adult C57BL/10ScSn mice after adenovirus-mediated gene transfer. Of the myofibers in the tibialis anterior muscle 62% were β-galactosidase positive after injection of the lacZ gene under the control of the chicken β-actin promoter and the cytomegalovirus enhancer. The transduced gene was preferentially expressed in type IIA and IIX fibers, which were richer in oxidative enzymes than type IIB fibers.
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页码：228 / 232
页数：4
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