Molecular Imaging of Phosphorylation Events for Drug Development

被引:0
作者
C. T. Chan
R. Paulmurugan
R. E. Reeves
D. Solow-Cordero
S. S. Gambhir
机构
[1] Stanford University School of Medicine,Department of Radiology
[2] Stanford University School of Medicine,Department of Bioengineering
[3] Stanford University School of Medicine,Division of Nuclear Medicine
[4] Stanford University School of Medicine,Molecular Imaging Program at Stanford (MIPS)
[5] Stanford University School of Medicine,Bio
[6] Stanford University School of Medicine,X Program
来源
Molecular Imaging and Biology | 2009年 / 11卷
关键词
Phosphorylation; Kinases; Noninvasive; Repetitive imaging in living subjects; Optical bioluminescence imaging in living subjects; Drug development; Akt;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:144 / 158
页数:14
相关论文
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[1]  
Paulmurugan R(2006)An intramolecular folding sensor for imaging estrogen receptor–ligand interactions Proc Natl Acad Sci U S A 103 15883-15888
[2]  
Gambhir SS(2007)Combinatorial library screening for developing an improved split-firefly luciferase fragment-assisted complementation system for studying protein–protein interactions Anal Chem 79 2346-2353
[3]  
Paulmurugan R(2005)Imaging protein–protein interactions in living subjects TrAC, Trends Anal Chem 24 446-580
[4]  
Gambhir SS(2003)Molecular imaging in living subjects: seeing fundamental biological processes in a new light Genes Dev 17 545-1107
[5]  
Paulmurugan R(2004)Molecular imaging of homodimeric protein–protein interactions in living subjects Faseb J 18 1105-315
[6]  
Massoud TF(2002)Protein kinases-the major drug targets of the twenty-first century? Nat Rev Drug Discov 1 309-5072
[7]  
Gambhir SS(1999)Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase Mol Cell Biol 19 5061-36641
[8]  
Massoud TF(2007)Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation J Biol Chem 282 36634-668
[9]  
Paulmurugan R(1997)Direct regulation of the akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate Science 275 665-5788
[10]  
Gambhir SS(2007)Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo PLoS Biol 5 e95-717