Tibia metastasis without Prostate Specific Antigen (PSA) increase following radical vesiculo-prostatectomy

被引：5

作者：

Hübler J. ^{[1
]}

Sükösd F. ^{[2
]}

Czipri M. ^{[3
]}

机构：

[1] Department of Urology, University Medical School, Pécs

[2] Department of Pathology, University Medical School, Ṕecs

[3] Departments of Orthopedic Surgery, University Medical School, Ṕecs

来源：

International Urology and Nephrology | 2000年 / 32卷 / 2期

关键词：

Follow-up; Metastasis; Prostate carcinoma; PSA (prostate specific antigen); Radical prostatectomy;

D O I：

10.1023/A:1007142910479

中图分类号：

学科分类号：

摘要：

Objectives: PSA is regarded as the best method in the follow-up of prostate carcinoma. After radical vesiculo-prostatectomy the prostate carcinoma seldom recurs at zero or nearly zero PSA levels. Methods: The authors have used PSA since 1989 and they have found only one case where metastasis in the tibia came without an increase in PSA levels. Results: Tibia metastasis showed lower tissue activity of PSA than did the primary tumor in the prostate. The authors think this explains the zero PSA level when the metastasis developed. Conclusions: The authors think based on their case that PSA free progression prostate cancers may cases where the metastases do not produce PSA.

引用

页码：281 / 284

页数：3

共 6 条

[1]

Partin A.W., Pound C.R., Clemens J.Q., Epstein J.I., Walsh P.C., Serum PSA in anatomic radical prostatectomy: The Johns Hopkins experience after 10 years, Urol Clin North Am, 20, pp. 713-725, (1993)

[2]

Aihara M., Lebovitz R.M., Wheeler T.M., Kinner B.M., Ohori M., Scardino P.T., Prostate specific antigen and Gleason grade: An immunohistochemical study of prostate cancer, J Urol, 151, pp. 1558-1564, (1994)

[3]

Goldrath D.E., Messing E.M., Prostate specific antigen not detectable despite tumor progression after radical prostatectomy, J Urol, 142, pp. 1082-1084, (1989)

[4]

Hudson M.A., Bahnson R.B., Catalona W.J., Clinical use of prostate specific antigen in patients with prostate cancer, J Urol, 142, pp. 1011-1017, (1989)

[5]

Leibmann B.D., Ozdal D., Wheeler T.M., Scardino P.T., Distant metastasis after radical prostatectomy in patients without an elevated serum prostate antigen level, Cancer, 76, pp. 2530-2534, (1995)

[6]

Takayama T.K., Krieger J.N., True L.D., Lange P.H., Recurrent prostate cancer despite undetectable prostate specific antigen, J Urol, 148, pp. 1541-1542, (1992)

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