Study of Association of Leptin and Insulin Resistance Markers in Patients of PCOS

被引：25

作者：

Nasrat H. ^{[1
]}

Patra S.K. ^{[1
]}

Goswami B. ^{[1
]}

Jain A. ^{[1
]}

Raghunandan C. ^{[2
]}

机构：

[1] Department of Biochemistry, Lady Hardinge Medical College, New Delhi

[2] Department of Obstetrics & Gynecology, Lady Hardinge Medical College, New Delhi

来源：

Indian Journal of Clinical Biochemistry | 2016年 / 31卷 / 1期

关键词：

HOMA-IR; Insulin resistance; Leptin; PCOS;

D O I：

10.1007/s12291-015-0499-8

中图分类号：

学科分类号：

摘要：

Polycystic ovary syndrome (PCOS) is a common endocrinological disorder among women of the reproductive age group with long term sequelae which include diabetes mellitus, hypertension and CAD. The present study was conducted to evaluate the association of leptin—an adipokine playing an important role in carbohydrate metabolism and markers of insulin resistance among women with PCOS. Sixty diagnosed cases of PCOS as per Rotterdam criteria were enrolled in this study after informed written consent. Insulin resistance was estimated using the homeostatic model assessment-insulin resistance (HOMA-IR). HOMA-IR was calculated as the product of the fasting plasma insulin value (mU/ml) and the fasting plasma glucose value (mg/dl), divided by 405 and HOMA β was calculated as 360 × [insulin]/([glucose] − 63) % (glucose in mg/dl). Estimation of serum leptin levels was done by ELISA using leptin ELISA kit from (DRG). A positive correlation of serum leptin levels was observed with markers of insulin resistance. Multiple regression analysis with HOMA-IR as dependent variable demonstrated a statistically significant contribution of fasting insulin levels. This study highlights the role of leptin in alterations in carbohydrate metabolism in patients with PCOS. © 2015, Association of Clinical Biochemists of India.

引用

页码：104 / 107

页数：3

共 14 条

[1]

Stein I., Leventhal M., Amenorrhea associated with bilateral polycystic ovaries, Am J Obstet Gynecol, 29, (1935)

[2]

Azziz R., Woods K.S., Reyna R., Key T.J., Knochenhauer E.S., Yildiz B.O., The prevalence and features of the polycystic ovary syndrome in an unselected population, J Clin Endocrinol Metab, 89, pp. 2745-2749, (2004)

[3]

Zawadzki J., Dunaif A., Diagnostic criteria for polycystic ovary syndrome: towards a rational approach, Polycystic ovary syndrome, pp. 377-384, (1992)

[4]

Franks S., Polycystic ovary syndrome, N Engl J Med, 333, pp. 853-861, (1995)

[5]

Hoeger K.M., Role of lifestyle modification in the management of polycystic ovary syndrome, Best Pract Res Clin Endocrinol Metab, 20, (2006)

[6]

Zhang Y.Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M., Positional cloning of the mouse obese gene and its human homolog, Nature, 372, pp. 425-432, (1994)

[7]

Leroy P., Dessolin S., Villageois P., Moon B.C., Friedman J.M., Ailhaud G., Et al., Expression of ob gene in adipose cells and regulation by insulin, J Biol Chem, 271, pp. 2365-2368, (1996)

[8]

Brzechffa P.R., Jakimiuk A.J., Agarwal S.K., Weitsman S.R., Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome, J Clin Endocrinol Metab, 84, pp. 4166-4169, (1996)

[9]

Mendonca H.C., Montenegro R.M., Foss M.C., Silva De Sa M.F., Ferriani R.A., Positive correlation of serum leptin with estradiol levels in patients with polycystic ovary syndrome, Braz J Med Biol Res, 37, pp. 729-736, (2004)

[10]

Fritz M.A., Speroff L., Clinical gynaecology endocrinology and infertility, (2011)

← 1 2 →