Checkpoint functions of RecQ helicases at perturbed DNA replication fork

被引：0
作者：
Nafees Ahamad
Saman Khan
Alaa Taha A. Mahdi
Yong-jie Xu
机构：
[1] Wright State University,Department of Pharmacology and Toxicology, Boonshoft School of Medicine
来源：
Current Genetics | 2021年 / 67卷
关键词：
DNA replication checkpoint; RecQ; Helicase; Sgs1; Rqh1; WRN; BLM; RECQ1; RECQ4; RECQ5; Replication stress; Genomic instability; ATR; Rad3; Mec1; CHK1; Cds1; SOS response; Fission yeast; Budding yeast;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains to be understood. Emerging evidence has shown that RecQ helicases, a large family of helicases that are conserved from bacteria to yeasts and humans, contribute to the replication checkpoint as sensors, adaptors, or regulation targets. Here, we highlight the multiple functions of RecQ helicases in the replication checkpoint in four model organisms and present additional evidence that fission yeast RecQ helicase Rqh1 may participate in the replication checkpoint as a sensor.
引用
收藏
页码：369 / 382
页数：13
相关论文
共 724 条
  • [1] Ahamad N(2020)RecQ DNA helicase Rqh1 promotes Rad3(ATR) kinase signaling in the DNA replication checkpoint pathway of fission yeast Mol Cell Biol 40 e00145-20
  • [2] Khan S(2010)ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery EMBO J 29 3156-3169
  • [3] Xu YJ(2010)Yeast as a model system to study RecQ helicase function DNA Repair (Amst) 9 303-314
  • [4] Ammazzalorso F(1985)Radiation sensitivity of Bloom's syndrome lymphocytes during S and G2 phases Cancer Genet Cytogenet 16 131-136
  • [5] Pirzio LM(2008)A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin Proc Natl Acad Sci USA 105 8580-8584
  • [6] Bignami M(2018)Single molecule kinetics uncover roles for Nucleic Acids Res 46 8500-8515
  • [7] Franchitto A(2013) RecQ DNA helicase domains and interaction with SSB DNA Repair (Amst) 12 751-760
  • [8] Pichierri P(1987)DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast Mutat Res 192 105-108
  • [9] Ashton TM(2008)Induction of the SOS response by hydroxyurea in Escherichia coli K12 Comput Biol Chem 32 349-358
  • [10] Hickson ID(2014)In silico analyses of a new group of fungal and plant RecQ4-homologous proteins Nucleic Acids Res 42 12628-12639
12345678910