BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

被引：0
作者：
Yu Meng
Hui-Yan Sun
Yi He
Qian Zhou
Yi-Huang Liu
Hui Su
Ming-Zhu Yin
Fu-Rong Zeng
Xiang Chen
Guang-Tong Deng
机构：
[1] Central South University,Department of Dermatology, Xiangya Hospital
[2] National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology,Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital
[3] Furong Laboratory,National Clinical Research Center for Geriatric Disorders
[4] Central South University,Department of Breast Reconstruction
[5] Xiangya Hospital,Department of Oncology, Xiangya Hospital
[6] Tianjin Medical University Cancer Institute and Hospital,undefined
[7] Central South University,undefined
来源：
Military Medical Research | / 10卷
关键词：
Melanoma; Bromodomain and extra terminal domain (BET) inhibitor; Ferroptosis; Cell death; AKR1C2; Immunotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 36 条
[1]  
He Y(2022)Multi-omics characterization and therapeutic liability of ferroptosis in melanoma Signal Transduct Target Ther 7 268-11443
[2]  
Dong Y(2020)BET inhibitor suppresses melanoma progression via the noncanonical NF-kappaB/SPP1 pathway Theranostics 10 11428-1062
[3]  
Chen Y(2017)Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation Nat Med 23 1055-376
[4]  
Zhang G(2019)Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis Cell Death Dis 10 902-274
[5]  
Zhang H(2023)BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression Exp Mol Med 55 364-undefined
[6]  
Lei G(2019)CD8 Nature 569 270-undefined
[7]  
Deng G(undefined) T cells regulate tumour ferroptosis during cancer immunotherapy undefined undefined undefined-undefined
[8]  
Zeng F(undefined)undefined undefined undefined undefined-undefined
[9]  
Su J(undefined)undefined undefined undefined undefined-undefined
[10]  
Zhao S(undefined)undefined undefined undefined undefined-undefined
1234