Postnatal decrease in substantia nigra echogenicityImplications for the pathogenesis of Parkinson’s disease

被引：0

作者：

Alexander Iova

Andrew Garmashov

Natalia Androuchtchenko

Martin Kehrer

Daniela Berg

Georg Becker†

Yurii Garmashov

机构：

[1] Saint-Petersburg Medical Academy of Postgraduate Education,Departments of Child Neurology and Neonatology

[2] Department of Child Neurology and Neurosurgery,Department of Neurology

[3] University Children’s Hospital,undefined

[4] Saarland University,undefined

[5] Institute for Medical Genetics,undefined

[6] Hertie Institute for Clinical Brain Research,undefined

来源：

Journal of Neurology | 2004年 / 251卷

关键词：

Parkinson’s disease; iron metabolism; transcranial ultrasound;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Increased echogenicity of the substantia nigra (SN) on transcranial ultrasonography (TCS) is a typical sign in Parkinson’s disease (PD). Detected in healthy adults it is assumed to represent a risk factor for nigral injury. We studied at which time point of brain maturation increased signal intensity may occur by performing TCS scans in 109 newborns and children aged 0–192 months. While newborns regularly exhibit SN hyperechogenicity, this echofeature decreases substantially during the first years of life. As SN echogenicity is related to the tissue iron content in adults our findings suggest a failure in SN iron metabolism in some children with increased echogenicity during development which can be disclosed by TCS.

引用

页码：1451 / 1454

页数：3

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