Ancylostoma ceylanicum and other zoonotic canine hookworms: neglected public and animal health risks in the Asia-Pacific region

被引：2

作者：

Tenorio, Jan Clyden B. ^{[1
,4
]}

Tabios, Ian Kim B. ^{[5
]}

Inpankaew, Tawin ^{[6
]}

Ybanez, Adrian P. ^{[7
,8
]}

Tiwananthagorn, Saruda ^{[9
,10
]}

Tangkawattana, Sirikachorn ^{[3
,11
]}

Suttiprapa, Sutas ^{[2
,3
]}

机构：

[1] Khon Kaen Univ, Fac Med, Trop Med Grad Program, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Fac Med, Dept Trop Med, Khon Kaen 40002, Thailand

[3] Khon Kaen Univ, WHO Collaborating Ctr Res & Control Opisthorchiasi, Trop Dis Res Ctr, Khon Kaen 40002, Thailand

[4] Univ Southern Mindanao, Coll Vet Med, Dept Vet Paraclin Sci, Cotabato 9407, Philippines

[5] Univ Philippines Diliman, Coll Sci, Inst Biol, Manila 1101, Philippines

[6] Kasetsart Univ, Fac Vet Med, Dept Parasitol, Bangkok 10900, Thailand

[7] Cebu Technol Univ, Coll Vet Med, Barili Campus, Cebu 6000, Philippines

[8] Cebu Technol Univ, Ctr Vector Borne & Protozoan Dis, Main Campus, Cebu 6000, Philippines

[9] Chiang Mai Univ, Fac Vet Med, Dept Vet Biosci & Publ Hlth, Chiang Mai 50100, Thailand

[10] Chiang Mai Univ, Res Ctr Vet Biosci & Vet Publ Hlth, Chiang Mai 50100, Thailand

[11] Khon Kaen Univ, Fac Vet Med, Khon Kaen 40002, Thailand

来源：

ANIMAL DISEASES | 2024年 / 4卷 / 01期

关键词：

Soil-transmitted helminths; Neglected tropical diseases; Mass drug administration; Deworming; Veterinary public health; TRANSMITTED HELMINTH INFECTIONS; CUTANEOUS LARVA MIGRANS; BENZIMIDAZOLE RESISTANCE; EOSINOPHILIC ENTERITIS; FECAL SAMPLES; SHELTER DOGS; PCR-RFLP; IDENTIFICATION; PARASITES; GENE;

D O I：

10.1186/s44149-024-00117-y

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Zoonotic hookworm infections remain a significant public health problem, causing nearly 500 million cases globally and approximately four million disability-adjusted life years lost annually. More than one-fifth of these cases are attributed to Ancylostoma ceylanicum, an emerging zoonotic health issue in the Asia-Pacific region. This review presents key research gaps regarding the epidemiology, diagnosis, control, prevention and elimination of A. ceylanicum and other canine zoonotic hookworms as neglected health threats. A. ceylanicum is the second most prevalent human hookworm in the region; it is the most common hookworm among dogs and cats-reservoirs of zoonotic infections. Previous population genetic and phylogenetic analyses revealed that A. ceylanicum has three possible transmission dynamics: zoonotic, animal-only, and human-only pathways. The actual burden of zoonotic ancylostomiasis in most endemic countries remains unknown due to the use of parasitological techniques (e.g., Kato-Katz thick smear and floatation techniques) that have reduced diagnostic performance and do not allow accurate species identification in helminth surveys. The emergence of benzimidazole resistance in soil-transmitted helminths (STHs), including hookworms, is a concern due to the protracted implementation of mass drug administration (MDA). Resistance is conferred by single nucleotide polymorphisms (SNPs) that occur in the beta-tubulin isotype 1 gene. These mutations have been reported in drug-resistant A. caninum but have not been found in A. ceylanicum in the field. A. ceylanicum remains understudied in the Asia-Pacific region. The zoonotic nature of the parasite warrants investigation of its occurrence in human and animal reservoir hosts to understand the dynamics of zoonotic transmission in different endemic foci. The detection of benzimidazole resistance-associated SNPs in zoonotic hookworms from Asia-Pacific countries has yet to be thoroughly explored. Considering the high level of hookworm endemicity in the region, the circulation of resistant isolates between humans and animals potentially presents a significant One Health threat that can undermine current MDA and proposed animal deworming-based control efforts.

引用

页数：16