A pilot study of regenerative therapy using controlled release of recombinant human fibroblast growth factor for patients with pre-collapse osteonecrosis of the femoral head

被引:0
作者
Yutaka Kuroda
Ryuta Asada
Kazutaka So
Atsushi Yonezawa
Manabu Nankaku
Kumi Mukai
Toshiko Ito-Ihara
Harue Tada
Michio Yamamoto
Toshinori Murayama
Satoshi Morita
Yasuhiko Tabata
Masayuki Yokode
Akira Shimizu
Shuichi Matsuda
Haruhiko Akiyama
机构
[1] Kyoto University,Department of Orthopaedic Surgery, Graduate School of Medicine
[2] Gifu University Hospital,Clinical Research Center
[3] Kyoto University Hospital,Department of Clinical Pharmacology and Therapeutics
[4] Kyoto University Hospital,Rehabilitation Unit
[5] Kyoto University Hospital,Department of Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Research (iACT)
[6] Kyoto University Hospital,Department of Data Science, Institute for Advancement of Clinical and Translational Research (iACT)
[7] Kyoto University Hospital,Department of Experimental Therapeutics, Institute for Advancement of Clinical and Translational Research (iACT)
[8] Kyoto University,Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences
[9] Gifu University,Department of Orthopaedic Surgery
来源
International Orthopaedics | 2016年 / 40卷
关键词
Clinical trial; Femoral head; FGF; Growth factor; Osteonecrosis; Regenerative therapy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1747 / 1754
页数:7
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  • [1] Hernigou P(2004)Fate of very small asymptomatic stage-I osteonecrotic lesions of the hip J Bone Joint Surg Am 86 2589-2593
  • [2] Ooignard A(2006)Nontraumatic osteonecrosis of the femoral head: Ten years later J Bone Joint Surg Am 88 1117-1132
  • [3] Nogier A(2008)Treatment of early stage osteonecrosis of the femoral head J Bone Joint Surg Am 90 175-187
  • [4] Manicom O(2015)Osteonecrosis repair with bone marrow cell therapies: State of the clinical art Bone 70 102-109
  • [5] Mont MA(2014)Stem cell treatment for avascular necrosis of the femoral head: current perspectives Stem Cells Clon 7 65-70
  • [6] Jones LC(2004)Treatment of osteonecrosis of the femoral head with core decompression and human bone morphogenetic protein Clin Orthop Relat Res 429 139-145
  • [7] Hngerford DS(2014)Recombinant human bone morphogenetic protein-2 in debridement and impacted bone graft for the treatment of femoral head osteonecrosis PLoS One 9 e100424-616
  • [8] Marker DR(2010)Treatment of experimental osteonecrosis of the hip in adult rabbits with a single local injection of recombinant human FGF-2 microspheres J Bone Miner Metab 28 608-605
  • [9] Seylee TM(2002)The 2001 revised criteria for diagnosis, classification, and staging of idiopathic osteonecrosis of the femoral head J Orthop Sci 7 601-2175
  • [10] McGrath MS(1999)Vascularization into a porous sponge by sustained release of basic fibroblast growth factor Biomaterials 20 2169-856