Autonomic regulation therapy in heart failure

被引：40
作者：
Buckley U. [1 ,4 ]
Shivkumar K. [1 ,3 ]
Ardell J.L. [1 ,2 ]
机构：
[1] Cardiac Arrhythmia Center, Neurocardiology Research Center of Excellence, UCLA David Geffen School of Medicine, 100 Medical Plaza, Suite 660, Los Angeles, 90095, CA
[2] Department of Medicine (Cardiology), UCLA Health System, 47-126 CHS, Los Angeles, 90095, CA
[3] Interventional Cardiovascular Programs, UCLA Health System, Los Angeles, 90095, CA
[4] UCLA Cardiac Arrhythmia Center, UCLA Health System, Los Angeles, 90095, CA
来源：
Current Heart Failure Reports | 2015年 / 12卷 / 4期
基金：
美国国家卫生研究院;
关键词：
Baroreceptor stimulation; Heart failure; Renal denervation; Spinal cord stimulation; Sympathetic modulation; Vagus nerve stimulation;
D O I：
10.1007/s11897-015-0263-7
中图分类号：
学科分类号：
摘要：
Autonomic regulation therapy (ART) is a rapidly emerging therapy in the management of congestive heart failure secondary to systolic dysfunction. Modulation of the cardiac neuronal hierarchy can be achieved with bioelectronics modulation of the spinal cord, cervical vagus, baroreceptor, or renal nerve ablation. This review will discuss relevant preclinical and clinical research in ART for systolic heart failure. Understanding mechanistically what is being stimulated within the autonomic nervous system by such device-based therapy and how the system reacts to such stimuli is essential for optimizing stimulation parameters and for the future development of effective ART. © Springer Science+Business Media New York 2015.
引用
收藏
页码：284 / 293
页数：9
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