Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity

被引：0
作者：
Noha A. Irani-Hakime
Farid Stephan
Raghid Kreidy
Isabelle Jureidini
Wassim Y. Almawi
机构：
[1] St. Georges University Hospital,Department of Laboratory Medicine
[2] St. Georges University Hospital,Department of Dermatology
[3] St. Georges University Hospital,Department of Vascular Surgery
[4] Arabian Gulf University,Department of Medical Biochemistry
来源：
Journal of Thrombosis and Thrombolysis | 2008年 / 26卷
关键词：
Livedoid vasculopathy; Factor V-Leiden; Prothrombin G20210A; MTHFR C677T;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Livedoid vasculopathy (LV) is an occlusive thrombotic disease of lower extremities. A 34-year-old woman presented with 4-year history of recurrent necrotic and painful lesions with violaceous and purpuric border on both legs. Initial treatment with hydroxychloroquine, dapsone and prednisone were unsuccessful. Skin biopsy showed inflammatory infiltrate with epidermal necrosis. Prothrombin G20210A and factor V-Leiden heterozygosity, and MTHFR C677T homozygosity with hyperhomocysteinemia were confirmed. LV diagnosis was made; acetylsalicylic acid, folic acid, vitamin B12, and prednisone treatement resulted in complete healing. This is the first report on coexistence of prothrombin G20210A, factor V-Leiden, and homozygous MTHFR C677T with hyperhomocysteinemia in LV.
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页码：31 / 34
页数：3
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