Diagnostic evaluation of PSA recurrence and review of hormonal management after radical prostatectomy

被引:0
作者
H Van Poppel
S Joniau
B Van Cleynenbreugel
F M Mottaghy
R Oyen
机构
[1] University Hospital,Department of Urology
[2] University Hospital,Department of Nuclear Medicine
[3] University Hospital,Department of Radiology
来源
Prostate Cancer and Prostatic Diseases | 2009年 / 12卷
关键词
androgen deprivation; hormonal therapy; prostate cancer recurrence; radical prostatectomy;
D O I
暂无
中图分类号
学科分类号
摘要
The aim of this review is to provide a discussion of the diagnostic evaluation of biochemical recurrence following radical prostatectomy (RP) and an overview of the postoperative hormonal treatment (HT) options. As no randomized trials in the clinical setting of postoperative prostate-specific antigen recurrence have been reported, there is no conclusive evidence that HT after RP will prolong survival or reduce morbidity. Non-traditional approaches, such as intermittent androgen deprivation, non-steroidal anti-androgens and combination of finasteride and non-steroidal anti-androgen, are investigated and may be acceptable options. Combinations of HT with radiotherapy and/or chemotherapy for treatment of recurrent prostate cancer are under study.
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页码:116 / 123
页数:7
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  • [1] Messing EM(1999)Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer N Engl J Med 341 1781-1788
  • [2] Manola J(2006)Immediate versus deferred androgen deprivation treatment in patients with node positive prostate cancer after radical prostatectomy and pelvic lymhadenectomy Lancet Oncol 7 472-479
  • [3] Sarosdy M(2001)Defining prostate specific antigen progression after radical prostatectomy: what is the most appropriate cut point? J Urol 165 1146-1151
  • [4] Wilding G(2003)Defining the ideal cutpoint for determining PSA recurrence after radical prostatectomy. Prostate-specific antigen Urology 61 365-369
  • [5] Crawford ED(2007)Variation in the definition of biochemical recurrence in patients treated for localized prostate cancer: the American Urological Association Prostate Guidelines for Localized Prostate Cancer Update Panel report and recommendations for a standard in the reporting of surgical outcomes J Urol 177 540-545
  • [6] Trump D(2008)EAU guidelines on prostate cancer Eur Urol 53 68-80
  • [7] Messing EM(2004)Management of patients with an increasing prostate-specific antigen after radical prostatectomy Curr Urol Rep 5 179-187
  • [8] Manola J(1999)Natural history of progression after PSA elevation following radical prostatectomy JAMA 281 1591-1597
  • [9] Yao J(2005)Radical prostatectomy: long-term cancer control and recovery of sexual and urinary function (‘trifecta’) Urology 66 83-94
  • [10] Kiernan M(2007)Radical prostatectomy for clinically localized, high risk prostate cancer: critical analysis of risk assessment methods J Urol 178 493-499