Engineering CAR-T cells

被引：0
作者：
Cheng Zhang
Jun Liu
Jiang F. Zhong
Xi Zhang
机构：
[1] Xinqiao Hospital,Department of Hematology
[2] Third Military Medical University,Division of Periodontology, Diagnostic Sciences & Dental Hygiene, and Division of Biomedical Sciences, Herman Ostrow School of Dentistry
[3] University of Southern California,undefined
来源：
Biomarker Research | / 5卷
关键词：
Chimeric antigen receptor redirected T cells; CAR-T cells; Structure; Evolution; Production; Viral vector;
D O I：
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摘要：
Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients’ or donors’ blood. After the T cells are expanded and genetically modified, they are reinfused into the patients. However, many challenges still need to be resolved in order for this technology to gain widespread adoption. In this review, we first discuss the structure and evolution of chimeric antigen receptors. We then report on the tools used for production of CAR-T cells. Finally, we address the challenges posed by CAR-T cells.
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