The association between neonatal vitamin D status and risk of schizophrenia

被引：0
作者：
Darryl W. Eyles
Maciej Trzaskowski
Anna A. E. Vinkhuyzen
Manuel Mattheisen
Sandra Meier
Helen Gooch
Victor Anggono
Xiaoying Cui
Men Chee Tan
Thomas H. J. Burne
Se Eun Jang
David Kvaskoff
David M. Hougaard
Bent Nørgaard-Pedersen
Arieh Cohen
Esben Agerbo
Carsten B. Pedersen
Anders D. Børglum
Ole Mors
Pankaj Sah
Naomi R. Wray
Preben B. Mortensen
John J. McGrath
机构：
[1] University of Queensland,Queensland Brain Institute
[2] St. Lucia,Queensland Centre for Mental Health Research
[3] The Park Centre for Mental Health,Institute for Molecular Bioscience
[4] Wacol,Department of Biomedicine
[5] The University of Queensland,iPSYCH
[6] Aarhus University,Clem Jones Centre for Ageing Dementia Research
[7] The Lundbeck Foundation Initiative for Integrative Psychiatric Research,Center for Neonatal Screening
[8] Mental Health Centre for Child and Adolescent Psychiatry,National Centre for Register
[9] Copenhagen Region,Based Research
[10] University of Queensland,Centre for Integrated Register
[11] Department for Congenital Disorders,based Research
[12] Statens Serum Institut,Department of Biomedicine and iSEQ
[13] Aarhus University,Centre for Integrative Sequencing
[14] Aarhus University,undefined
[15] Aarhus University,undefined
[16] Psychosis Research Unit,undefined
[17] Aarhus University Hospital,undefined
[18] Psychiatry,undefined
来源：
Scientific Reports | / 8卷
关键词：
25OHD Concentrations; Schizophrenia Polygenic Risk Scores; Quintile Comparison; Selected Single Nucleotide Polymorphisms (SNPs); Neonatal 6-OHDA;
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摘要：
Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophrenia. We wish to explore this hypothesis in a large Danish case-control study (n = 2602). The concentration of 25 hydroxyvitamin D (25OHD) was assessed from neonatal dried blood samples. Incidence rate ratios (IRR) were calculated when examined for quintiles of 25OHD concentration. In addition, we examined statistical models that combined 25OHD concentration and the schizophrenia polygenic risk score (PRS) in a sample that combined the new sample with a previous study (total n = 3464; samples assayed and genotyped between 2008-2013). Compared to the reference (fourth) quintile, those in the lowest quintile (<20.4 nmol/L) had a significantly increased risk of schizophrenia (IRR = 1.44, 95%CI: 1.12–1.85). None of the other quintile comparisons were significantly different. There was no significant interaction between 25OHD and the PRS. Neonatal vitamin D deficiency was associated with an increased risk for schizophrenia in later life. These findings could have important public health implications related to the primary prevention of schizophrenia.
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